This extract has been used in multiple cancer types and has demonstrated reliable mechanisms of action to weaken cancer both independently and in conjunction with traditional American chemotherapy. Ample research to backup its use and benefits, even in stage 4 cancers.
To view the literature go to the website: American Bioscience (click below)
Direct Link to literature: https://fwgeresearch.org/fwge-clinical-trials
To see the research, click on the link below to review human trials:
It weakens cancer thru multiple mechanisms of action:
Mechanism of Action of Metatrol (previously named Ave or Avemar)
1. PARP – (poly ADP ribose polymerase) enzyme is a key player in DNA repair and has high activity in cancer cells. Metatrol increases caspase 3 which breaks down PARP inducing apoptosis (cell death) as the cancer cell can’t repair its own DNA.
2. ICAM-1 (intercellular adhesion molecule 1)
Endothelial cells in vasculature of tumors have decreased expression of ICAM-1, which impairs leukocytes (white blood cells) ability to infiltrate the tumor. Metatrol upregulates ICAM-1 thereby allowing macrophages to penetrate the wall of the vessels and enter the tumor to kill it.
3. TNF-alpha is an anti-cancer cytokine and is upregulated by Metatrol
4. MHC-1 (major histocompatability factor 1) acts to cloak tumor cells and shield them from immune cell recognition. A type of camouflage. Metatrol decreases MHC-1 protein levels on the surface of tumors thus exposing them to natural killer cell activity.
5. COX 1 & 2 - is inhibited by Metatrol. Therefore has benefit in auto-immune disease such as rheumatoid. Also preventive in colorectal cancer.
6. PPP – (pentose phosphate pathway) Metatrol inhibits glucose consumption
Metatrol interferes with cancer cells ability to form ribose from glucose. Can’t make ribosomal RNA fractions for protein synthesis and also effects fatty acid synthesis. Metatrol decreases the activity of glucose-6-phosphate dehydrogenase and transketolase thereby decreasing glucose uptake. The result is decreased RNA production, decreased protein synthesis and reproduction.
GLUTEN – it does have a tiny amount of gluten so if celiac the risk has to be weighed but the active compound is “benzyl quinone” not wheat.
LINK to literature https://fwgeresearch.org/fwge-research-articles